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KMID : 0361920060360060465
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Korean Journal of Orthodontics
2006 Volume.36 No. 6 p.465 ~ p.473
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Effects of nitric oxide on the proliferation and differentiation of human periodontal ligament cells
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Choi Sun-Young
Cho Jin-Hyung
Kang Kyung-Hwa
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Abstract
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This study evaluated the effects of nitric oxide (NO) on the proliferation and differentiation of human periodontal ligament cells involved in orthodontic tooth movement.
Methods:A range of concentrations of sodium nitroprusside (SNP), a NO donor, were administered to samples of human periodontal ligament cells, followed by measurement of cell viability, alkaline phosphatase (ALP) activity, and expression of osteonectin and bone sialoprotein.
Results:Cell viability, ALP activity and the expression of osteonectin and bone sialoprotein were increased in human periodontal ligament cells treated with SNP concentrations of < 0.2 mM compared with controls, but were decreased with SNP concentrations of > 1.0 mM.
Conclusion:NO has a biphasic effect on proliferation and differentiation in human periodontal ligament cells, with a stimulatory effect at low concentrations and an inhibitory effect at high concentrations
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KEYWORD
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Nitric oxide, Human periodontal ligament cells, Growth and differentiation
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